Gene expression and sequencing analyses of TLR7, TLR8, TLR9, SOD3, CAT, and GPX were performed in both groups, and single nucleotide polymorphisms (SNPs) were detected.<h4>Results and discussion</h4>Clinically affected cattle exhibit pyrexia (40-41 °C) and characteristic nodular skin lesions. The gene discussed is SOD3; the disease is Fever.