Multivariate analysis identified the tumor volume, maximum tumor diameter, depth of tumor invasion, maximum short-axis diameter of regional lymph nodes, Carcinoembryonic Antigen level, Neutrophil-to-Lymphocyte Ratio (NLR), standard deviation of CT value of tumor parenchyma, and Rad-score as independent predictors of LVI (P<0.05). This evidence concerns the gene CEACAM5 and neoplasm.