Gene expression analyses revealed subtype-specific alterations in DNA repair genes across leukemia datasets.<h4>Conclusions</h4>Several DNA repair polymorphisms, including <i>XPD Lys751Gln, XPC Lys939Gln, XRCC1 Arg194Trp, XRCC1 Arg399Gln</i>, and <i>XRCC3 Thr241Met</i>, are associated with increased leukemia susceptibility. This evidence concerns the gene XRCC1 and leukemia.