DHODH and schistosomiasis: Therefore, from the computational and experimental approaches employed in this study, we were able to understand a possible mechanism related to the <i>Sm</i>DHODH inhibition and the discovery of a potential bioactive compound against this important target related to schistosomiasis.<h4>Supplementary information</h4>The online version contains supplementary material available at 10.1007/s40203-026-00628-1.