<h4>Objective</h4>To investigate the predictive value of preoperative serum thyroglobulin (Tg) and anti-thyroglobulin antibodies (TgAb) for central compartment lymph node metastasis (CLNM) in patients with clinically node-negative (cN0) papillary thyroid carcinoma (PTC).<h4>Methods</h4>A retrospective analysis was conducted on clinical data from patients with cN0 PTC who underwent total thyroidectomy with central compartment lymph node dissection at our hospital between January 2018 and December 2023. This evidence concerns the gene TG and differentiated thyroid carcinoma.