C1QTNF4 transgenic (Tg) mice and their corresponding littermate controls were subjected to either a high-fat (HF) diet (HFD) or a standard chow diet for 14 weeks.<h4>Results</h4>C1QTNF4 and leptin levels increased, while adiponectin levels decreased in subjects with obesity and DM compared to normal individuals. Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.