AQP1 and urinary bladder cancer: Among these, compounds 8 (Clematignoside), 10 (Ginsenoside Rb2), and 15 (Tannic acid) demonstrated particularly strong binding affinity and complex stability in molecular dynamics simulations.<h4>Conclusion</h4>These findings provide a valuable foundation for the rational design of AQP1-targeted pharmacophores and suggest promising candidates for the future development of clinical drugs for the treatment of bladder cancer.