Cytokines(interleukins 10 and 6) in plasma were detected by enzyme-linked immunosorbent assay.<h4>Results</h4>The skin microbiome in the pruritus group was characterized by a significant depletion of protective commensals, specifically <i>Cutibacterium</i> and the <i>Burkholderia-Caballeronia-Paraburkholderia</i>. This evidence concerns the gene IL10 and Pruritus.