The resulting multivariable logistic regression nomogram - incorporating NK cell count, C-reactive protein, corticosteroid use history, and Gram-positive bacterial co-infection - demonstrated robust discrimination (AUC = 0.878, 95% CI: 0.789-0.967), with good calibration (Hosmer-Lemeshow <i>p</i> = 0.849) and stability on internal validation (cross-validated AUC = 0.860).<h4>Conclusion</h4><i>Aspergillus</i> and <i>Mucorales</i> co-infection constitutes a distinct, high-mortality clinical entity in the ICU. This evidence concerns the gene CRP and coinfection.