Subsequently, the effect of ITPKA on GBM growth was evaluated in a nude mouse subcutaneous tumor xenograft model.<h4>Results</h4>Overexpression of ITPKA significantly inhibited the proliferation, migration, and invasion capabilities of GBM cells of the two GBM cell lines <i>in vitro</i> and the progression of subcutaneous xenograft tumors of two GBM cell lines in nude mice <i>in vivo</i>. This evidence concerns the gene ITPKA and glioblastoma.