This study investigated the expression patterns of ITPKA in gliomas and explored its functional role in glioblastoma (GBM), thereby providing new insights into the diagnostic and prognostic evaluations of ITPKA in this disease.<h4>Methods</h4>ITPKA expression levels in glioma tissues of different World Health Organization (WHO) grades and GBM cell lines were measured using reverse transcription quantitative polymerase chain reaction (RT-qPCR) and Western blotting. This evidence concerns the gene ITPKA and central nervous system cancer.