Diagnostic performance was evaluated via group comparisons, Spearman correlation, and receiver operating characteristic curve analysis.<h4>Results</h4>MMP-7 levels were significantly higher in PBC patients compared with healthy controls [5.12 (3.73-6.97) vs. 2.46 (1.93-2.84) ng/mL, <i>p</i> < 0.001], and further elevated in cirrhotic vs. non-cirrhotic [6.99 (5.80-11.80) vs. 4.11 (3.59-5.25) ng/mL] and in advanced vs. early fibrosis [7.13 (5.78-11.02) vs. 3.83 (3.52-5.61) ng/mL; <i>p</i> < 0.001]. The gene discussed is MMP7; the disease is primary biliary cholangitis.