This improvement was accompanied by restoration of mitochondrial structure and function.<h4>Conclusion</h4>EMPA treatment effectively improves cardiac structure and function in MI mice, potentially through regulating lipid metabolism and reducing tissue EA levels, thereby inhibiting NF-κB/NLRP3/pyroptosis while alleviating mitochondrial structural and functional abnormalities. The gene discussed is NFKB1; the disease is myocardial infarction.