Immunofluorescence validated elevated insulin-like growth factor binding protein 2 (<i>IGFBP2</i>), procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 (<i>PLOD2</i>), and <i>VEGFA</i> in AD tissues, supporting their roles in matrix remodeling and angiogenesis. Here, PLOD2 is linked to Alzheimer disease.