CDKN2A and gestational diabetes: Interaction analysis revealed that the wild-type alleles of rs2383208 and rs10811661 interacted with O<sub>3</sub>, increasing the risk of GDM, while the wild-type allele of rs10811661 also interacted with PM<sub>2.5</sub>, further elevating GDM risk.<h4>Conclusion</h4>CDKN2A/2B gene polymorphisms, haplotypes, environmental exposure to O<sub>3</sub> and PM<sub>2.5</sub>, and gene-environment interactions contribute to an increased risk of GDM in Chinese women.<h4>Trial registration</h4>Chinese Clinical Trial Registry, chictr.org.cn, ChiCTR2000029178.