<h4>Introduction</h4>This study investigates the association between the cyclin-dependent kinase inhibitor 2A/2B (<i>CDKN2A/2B</i>) gene and gestational diabetes mellitus (GDM) in Chinese women, with a focus on potential gene-environment interactions.<h4>Methods</h4>A case-control study was conducted with 1,566 pregnant women from Beijing, Wuhan, and Zunyi, China. Here, CDKN2A is linked to gestational diabetes.