Extracellular matrix (ECM) remodeling was strongly pro-fibrotic in leiomyomas, with significant upregulation of several TGFB-regulated and related genes, a disrupted balance of KLF regulators, including loss of the anti-fibrotic repressor <i>KLF10</i> and induction of the pro-fibrotic <i>KLF5</i> factor, and broad upregulation of integrins. The gene discussed is TGFB1; the disease is leiomyoma.