The meta-analysis findings were consistent with the overall lack of association between MTRR rs162036 and cancer risk, while supporting a potential role for PPAR-γ rs1801282 in cancer susceptibility.<h4>Conclusions</h4>The PPAR-γ rs1801282 polymorphism may serve as a potential genetic marker for NSCLC risk in Egyptians, whereas MTRR rs162036 shows no significant impact. Here, PPARG is linked to cancer.