Regression analyses revealed that HbA1c and age significantly contributed to increased CVD in DM and that Lp(a) was determined by FT3 and albumin (Alb) in DM; ROC curves demonstrated that the combination of Lp(a) with traditional parameters significantly enhanced the AUC for CVD in DM.<h4>Conclusion</h4>Elevated Lp(a) levels are significantly associated with CVD and demonstrate strong discriminative utility, particularly in patients with DM. The gene discussed is ALB; the disease is diabetes mellitus.