In addition, the ROC curves of each variable analyzed separately showed that ORM2 (AUC = 0.777), ORM1 (AUC = 0.720), MONO (AUC = 0.638) and AGP (AUC = 0.673) all had different degrees of predictive ability for the risk of psoriasis.<h4>Conclusion</h4>The novel biomarker combinations with stable and high expression in the early stage have shown great potential in the research of psoriasis. This evidence concerns the gene ORM1 and psoriasis.