This study aims to evaluate the diagnostic value of monocytes (MONO), Orosomucoid-1 (ORM1), Orosomucoid-2 (ORM2), and Alpha-1-acid glycoprotein (AGP), and to develop a nomogram for the objective and early identification of psoriasis.<h4>Methods</h4>This retrospective case-control study included 140 participants, comprising 70 patients with psoriasis confirmed by the dermatology department and 70 healthy individuals who underwent routine health examinations during the same period. The gene discussed is ORM1; the disease is psoriasis.