Flow cytometry analysis was used to analyze the tumor immune microenvironment.<h4>Results</h4>Mn<sub>3</sub>O<sub>4</sub>/QD@LM functioned as a "ROS amplifier" by exhibiting catalase-like and glutathione peroxidase-like activities, which alleviated tumor hypoxia and depleted GSH, thereby markedly enhancing SDT efficacy. The gene discussed is CAT; the disease is neoplasm.