FOXM1 and neoplasm: Transcriptome analysis was performed to elucidate the molecular mechanisms by which FOXM1 promotes fibrosis and tumor progression.<h4>Results</h4>Mechanistically, P49-PROTAC<sup>VHL</sup> recruited FOXM1 to the VHL E3 ligase, leading to its polyubiquitination and subsequent proteasomal degradation.