In the DEN/CCl<sub>4</sub> model, P49-PROTAC<sup>VHL</sup> modulated the FOXM1-ADAMTS12 axis, thereby mitigating fibrosis and suppressing hepatocarcinogenesis.<h4>Conclusions</h4>The FOXM1-ADAMTS12 axis may represent an important molecular link between liver fibrosis and hepatocarcinogenesis. This evidence concerns the gene VHL and Hepatic fibrosis.