The relative importance of hematopoietic vs non-hematopoietic expression of STAT1 in restricting CR6 replication and maintaining tissue homeostasis was assessed in bone marrow chimeras.<h4>Results</h4>MNV CR6 <i>Stat1</i> <sup>KO</sup> mice developed severe hepatitis with patchy hepatocellular necrosis and localized enrichment of CR6-infected myeloid cells, particularly macrophages. This evidence concerns the gene STAT1 and Hepatitis.