SHBG and metabolic disease: To better understand relationships and underlying mechanisms, we develop summary proteomics and metabolomics scores for sex hormones and investigate their associations with sleep and metabolic disorders.<h4>Methods</h4>We used proteome- (n= 3680) and metabolome- wide (n= 1649) data from the baseline exam of the Multi-Ethnic Study of Atherosclerosis (MESA) cohort to develop female- and male-specific omics scores for sex hormones including total (Total T), bioavailable (Bio T), and free (Free T) testosterone, estradiol (E2) and sex hormone binding protein (SHBG).