To better understand relationships and underlying mechanisms, we develop summary proteomics and metabolomics scores for sex hormones and investigate their associations with sleep and metabolic disorders.<h4>Methods</h4>We used proteome- (n= 3680) and metabolome- wide (n= 1649) data from the baseline exam of the Multi-Ethnic Study of Atherosclerosis (MESA) cohort to develop female- and male-specific omics scores for sex hormones including total (Total T), bioavailable (Bio T), and free (Free T) testosterone, estradiol (E2) and sex hormone binding protein (SHBG). This evidence concerns the gene SHBG and Other metabolic disease.