The biomarker model (sTNFR1, sTNFR2, cystatin C, eGFR) measured at Day 90 discriminated those with MAKE365 with an AUC of 0.79 [95% confidence interval (CI) 0.68-0.91], and kidney disease progression with AUC 0.79 (95% CI 0.67-0.91). The gene discussed is CST3; the disease is kidney disorder.