SYF2 and osteoarthritis: We employed single-cell sequencing and machine learning techniques to predict SYF2 as a potential therapeutic target for osteoarthritis and the underlying mechanisms involved.<h4>Methods</h4>Single-cell dataset (GSE220243), cartilage tissue gene expression profiles (GSE169077, GSE117999, GSE53857) and blood sample expression profile (GSE48556) were obtained.