Consistent with these findings, flow cytometry analysis showed that <i>ItgaxΔPtpn6</i> mice injected with MC38 tumor and treated with anti-PD1 displayed a reduction in CD8<sup>+</sup> IFN-γ cells in comparison with <i>Ptpn6 <sup>f/f</sup></i> littermates.<h4>Conclusions</h4>These results show that SHP-1 depletion in CD11c<sup>+</sup> cells impairs anti-tumor immunity and suggest that both cDC1s and macrophages contribute to this effect. Here, PTPN6 is linked to neoplasm.