The ICIs-related myocarditis mouse model showed elevated myocardial injury markers (BNP, CK-MB, cTnT) and decreased cardiac function indicators (LVEDV, LVEF, LVIDd, LVIDs) compared to the normal group (<i>P</i> < 0.05 or <i>P</i> < 0.01). The gene discussed is NPPB; the disease is myocarditis.