TLR7 and HIV infectious disease: However, it remains unclear whether TLR7-driven immune responses differ by sex in the context of HIV infection.<h4>Methods</h4>We characterized sex-specific immune responses to TLR7 stimulation in a cohort of 1,326 antiretroviral therapy (ART)-suppressed individuals living with HIV (192 women, 1,134 men), including 50 spontaneous HIV controllers, and in 43 people living without HIV (28 women, 15 men).