PDEVs enhanced inflammatory cytokine production IL-4, IL-5, IL-13, IL-33 expression, and promoted eosinophilic, neutrophilic infiltration in murine.<h4>Conclusion</h4>Our findings suggest extracellular vesicles present in pollen grains, which may represent a critical mechanism underlying pollen-induced airway inflammation. This evidence concerns the gene IL5 and inflammation.