This study aimed to evaluate the diagnostic and prognostic value of Ki-67, alpha-fetoprotein (AFP), and lactate dehydrogenase (LDH), individually and in combination.<h4>Methods</h4>We retrospectively analyzed 82 pediatric patients (≤18 years) with histologically confirmed ovarian teratomas, including 45 mature and 37 immature cases. This evidence concerns the gene MKI67 and ovarian teratoma.