Integration of druggability assessment with multi-tissue eQTL analyses prioritized FES, CCN3, NMI, and NMT1 as promising therapeutic candidates for COPD.<h4>Conclusion</h4>These findings provide genetic evidence supporting a causal relationship between EOA and COPD, reveal putative mediating proteins, and prioritize therapeutic candidates with translational potential, offering new insights into pathogenesis, prevention, and intervention. This evidence concerns the gene FES and chronic obstructive pulmonary disease.