Nine genes with strong impact on signaling pathways (<i>ATP6V0B</i>, <i>F3</i>, <i>FUCA1</i>, <i>FTL</i>, <i>HNRNPR</i>, <i>ID3</i>, <i>JUN</i>, <i>MIIP</i>, and <i>PGM1</i>) and 6 partially overlapping genes with strong impact on immune pathways (<i>F3</i>, <i>FTL</i>, <i>FOSB</i>, <i>IFI6</i>, <i>ISG15</i>, and <i>SPINT2</i>) were consistently predicted in at least 2 of the 3 analyzed oligodendrogliomas. Here, SPINT2 is linked to oligodendroglioma.