We report on a study investigating the role of TP53 mutations among HPV DNA-positive cervical and vulvar tissue from Zimbabwean WLWH.<h4>Methods</h4>This cross-sectional study recruited 102 WLWH aged over 18 years, with histologically confirmed vulvar (<i>n</i> = 13) or cervical disease (<i>n</i> = 89). This evidence concerns the gene TP53 and cervicitis.