Therefore, we evaluated its determinants and its association with mortality risk in patients with CKD stages 3-5.<h4>Methods</h4>In this cross-sectional study with longitudinal follow-up, erythroferrone, hepcidin, ferritin, transferrin saturation (TSAT), C-reactive protein (CRP) and nutritional status were assessed in 377 CKD patients [92 patients with CKD stages 3-4, 210 non-dialysed patients with CKD stage 5 and 75 patients on peritoneal dialysis (PD)]. This evidence concerns the gene HAMP and chronic kidney disease.