<h4>Background</h4>Pathogenic variants in the <i>COL4A4</i> gene lead to Alport syndrome, a hereditary kidney disorder characterized by deficiencies in the glomerular basement membrane (GBM), progressive renal failure, and associated visual and auditory dysfunctions.<h4>Objective</h4>This study is aimed at detecting genetic variants and conducting an integrative network analysis to elucidate their involvement in Alport syndrome and chronic kidney disease (CKD).<h4>Methodology</h4>The enrolled patients were biological sisters. The gene discussed is COL4A4; the disease is chronic kidney disease.