When applied to peripheral blood mononuclear cell (PBMC) samples from hepatocellular carcinoma (HCC) patients, GenPath-PPH not only identifies well-known cancer-associated pathways (e.g., JAK-STAT signaling, p53 signaling and the pentose phosphate pathway) in accordance with other techniques, but also reveals additional pathways (e.g., NF- κ B signaling, sphingolipid signaling and aminoacyl-tRNA biosynthesis) that are either missed by other techniques, despite their known relevance to HCC, or represent novel candidate pathways for experimental evaluation. Here, TP53 is linked to cancer.