Ruxolitinib partially attenuated infection-associated expansion of myeloid-derived suppressor cell subsets.<h4>Discussion</h4>Overall, STAT1-L351F was associated with impaired antifungal control, selective ex vivo permissiveness to distinct fungal pathogens, and altered IL-17-linked immune programs during T. marneffei infection, providing a multi-layered framework for understanding how dysregulated STAT1 signaling may reshape antifungal immunity across human, cell-based, and in vivo systems. Here, IL17A is linked to infection.