CD4 and Alzheimer disease: Epigenetic profiling further revealed disease-associated chromatin regions linked to transcription factors involved in immune regulation.<h4>Conclusion</h4>Both CD4<sup>+</sup>CLA<sup>+</sup> and CD4<sup>+</sup> naïve T cells exhibit transcriptomic and epigenetic alterations in AD and Ps, suggesting the influence of the chronic inflammatory milieu leading to shared and disease-specific changes, including transcriptomic rewiring of the JAK-STAT pathway in both diseases.