MAPT and tauopathy: Consistent with these actions, circPDE4B knockdown strongly attenuated microtubule-associated protein tau pathology in a 3D human assembloid model of tauopathy.<h4>Discussion</h4>Collectively, our findings identify circPDE4B as a regulator of neuronal homeostasis that integrates translation, autophagy, and miRNA pathways, highlighting a potentially important role in the pathophysiology of AD.