Pooled adjusted estimates identified significant mortality predictors: older age, female sex, malignancy, chronic kidney disease, septic shock, higher APACHE II score, gas-formation, metastatic infection, anemia, thrombocytopenia, hypoalbuminemia, hyperbilirubinemia, elevated ALT, impaired renal function, bacteremia, <i>Escherichia coli</i> infection, anaerobic infection, multidrug-resistant organism infection, pneumonia, and ICU admission. The gene discussed is GPT; the disease is infection.