Cytokine profiling showed elevated levels of IL-6, IL-8, and IL-10, consistent with systemic inflammatory response syndrome (SIRS), with the mAb treatment showing a trend toward immune modulation.<h4>Conclusions</h4>This model successfully simulates human VREF bacteremia and demonstrates the therapeutic potential of mAb 8AP. Here, CXCL8 is linked to systemic inflammatory response syndrome.