C3AR1 and type 2 diabetes nephropathy: In this study, we used C57BLKS/JGpt wild-type (WT) mice, C57BLKS/JGpt db/db mice (a well-established model of type 2 diabetic nephropathy), and a pharmacological C3aR antagonist (C3aRA, SB290157 trifluoroacetate) to investigate this association.