This study aimed to assess the expression and function of Signal Inhibitory Receptor on Leukocytes-1 (SIRL-1) in IBD and to evaluate the diagnostic utility of the SIRL-1/IL-8 ratio.<h4>Methods</h4>Peripheral venous blood was collected from 90 participants (IBD patients and healthy volunteers). This evidence concerns the gene CXCL8 and inflammatory bowel disease.