Statistical analyses included Mann-Whitney U tests, Kruskal-Wallis tests, Spearman correlations, and Receiver Operating Characteristic (ROC) curve analysis.<h4>Results</h4>IBD patients exhibited significant downregulation of SIRL-1 protein and <i>VSTM1</i> messenger RNA in peripheral blood neutrophils. The gene discussed is VSTM1; the disease is inflammatory bowel disease.