Crucially, the SIRL-1/IL-8 ratio demonstrated superior diagnostic accuracy for distinguishing IBD from healthy controls (AUC = 0.82), outperforming individual markers, and was notably effective in Crohn's Disease (AUC = 0.86).<h4>Conclusions</h4>Deficiency in SIRL-1 appears to be a permissive factor for the pro-inflammatory IL-8 axis in IBD. Here, VSTM1 is linked to inflammatory bowel disease.