Nuclear factor erythroid 2-related factor 2 (NRF2) is a key antioxidant signaling molecule in sepsis, ischemia-hypoxic encephalopathy, and trauma, although its potential role(s) in heat stroke is unknown.<h4>Methods</h4>From January 2023 to June 2025, we enrolled patients with heat stroke and healthy volunteers at the General Hospital of the Southern Theater Command of the Chinese People's Liberation Army. This evidence concerns the gene NFE2L2 and Sepsis.