NFE2L2 and Heat Stroke: Nuclear factor erythroid 2-related factor 2 (NRF2) is a key antioxidant signaling molecule in sepsis, ischemia-hypoxic encephalopathy, and trauma, although its potential role(s) in heat stroke is unknown.<h4>Methods</h4>From January 2023 to June 2025, we enrolled patients with heat stroke and healthy volunteers at the General Hospital of the Southern Theater Command of the Chinese People's Liberation Army.