Experimental validation of SEC24B-AS1, a key lncRNA in the model, demonstrated its impact on tumor cell proliferation and migration, supporting the biological relevance of the prognostic signature in BLCA.<h4>Conclusion</h4>This study presents a novel migrasome-related lncRNA signature that independently predicts survival in bladder cancer and reflects the tumor immune landscape. The gene discussed is SEC24B; the disease is bladder transitional cell carcinoma.