In contrast, the FCER1G<sup>high</sup> Cytotoxic subset exhibited relative resistance to this depletion, explaining the observed subset inversion.<h4>Conclusion</h4>Our study demonstrates that hypertension induces a subset-specific remodeling of the human NK cell repertoire, characterized by a global reduction and pathogenic reshaping of the CD57<sup>+</sup>CD62L<sup>+</sup>CD161<sup>+</sup> NK cells. Here, SELL is linked to Hypertension.