(2) In the patients with vestibulo-oculomotor dysfunction, the plasma levels of IL-2 (3.40 ± 1.00 VS 2.13 ± 0.91, p=0.007), IL-17A (6.42 ± 3.59 VS 3.05 ± 2.13, p=0.021) and TNF-β (1.55 ± 0.41 VS 1.21 ± 0.37, p=0.030) were significantly elevated compared to the patients with normal vestibulo-oculomotor function.<h4>Conclusions</h4>Inflammation-mediated pathological mechanism, especially TNF-β-related pathways, is associated to both central and peripheral vestibular dysfunction in FD patients. This evidence concerns the gene IL2 and Fabry disease.