CD40 and neoplasm: These cells orchestrate a robust anti-tumor response via multi-faceted secretory signals (e.g., tumor necrosis factor, TNF; B-cell activating factor, BAFF) and contact-dependent interactions (e.g., CD40; major histocompatibility complex, MHC), effectively recruiting and activating immune effectors.<h4>Conclusion</h4>Our findings suggest that B cell-mediated immune surveillance may be a key mechanism contributing to the clearance of PT in OBC.