Although <i>DOCK7</i> mutations have been linked to human epileptic encephalopathies and neurodevelopmental dysfunction, we find that <i>Dock7</i> <sup>△ex3-4/△ex3-4</sup> male and female mice do not show heightened excitability or seizure susceptibilities using the repeated flurothyl seizure model.<h4>Highlights</h4><i>Dock7</i> <sup>△ex3-4/△ex3-4</sup> mice show slightly higher seizure thresholds during flurothyl kindling <i>Dock7</i> <sup>△ex3-4/△ex3-4</sup> mice do not exhibit heightened seizure susceptibility upon retest. Here, DOCK7 is linked to Epileptic encephalopathy.