IRF3 and idiopathic pulmonary fibrosis: Consistent with the network and transcription factor analyses, siRNA-mediated depletion of <i>IRF3</i> or <i>STAT1</i> significantly reduced IFN-β secretion in senescent healthy fibroblasts, whereas IPF fibroblasts showed only milder effects, indicating a disease-specific dependence on these pathways for antiviral control.