Based on patient sample analysis and signaling pathway investigation, the present study identifies peroxiredoxin 1 (PRDX1) as a potential therapeutic target for RCC.<h4>Methods</h4>Patient microarray analysis, combined with data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, revealed the expression pattern of PRDX1 in clear cell renal cell carcinoma (ccRCC) and confirmed its prognostic and diagnostic significance. This evidence concerns the gene PRDX1 and nonpapillary renal cell carcinoma.